Histomorphorlogical and biochemical evaluation of oral administration of datura metel stramonium on the kidneys of adult male wistar rats

Datura metel stramonium (leaves) extract has traditionally been used to treat swellings, burns, ulcers, asthma and sinus infections. However, report indicate that this plant is a strong poison linked delirium acute poisoning, which may result in death. Aim: Histomorphological potentials biochemical effects of on the kidneys adult male Wistar rats. Fresh leaves were harvested, cleaned, air-dried crushed into fine powder cold macerated 0.5 L 80% v/v methanol water for 72 hours resultant mixture was filtered using Whatman filter paper (No.1). The filtrate condensed dryness vapour at 400C bath, yielding 9g (18% w/w) semi-solid stored refrigerator 40C until use. Twenty-four (24) rats divided four (4) groups six (6) animals each. Groups 1 (0.2ml distilled water), 2 (200 mg/kg), 3 (400 4 (600 mg/kg) body weight/day had oral administration twenty-eight (28) days. sacrificed by cervical dislocation kidney tissues excised histomorphological examinations.